Available parameters and response documentation is available here

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HTTP 200 OK
Allow: GET, HEAD, OPTIONS
Content-Type: application/json ;utf-8
ETag: "1f57ec658a661aa124272be9d545371d32e0d0c6"
Vary: Accept

{
  "chromosome": "chr11",
  "alt": "",
  "ref": "A",
  "pos": 117222650,
  "variant_id": "10190111172226509001",
  "regions": {
    "UNIPROT UniProt Regions": {
      "20-Jun-2022": [
        {
          "PubMedIds": "18283122",
          "amino-acid": "M1-Y194",
          "protein": "CE164_HUMAN",
          "type": "region of interest",
          "length": 23847,
          "description": "Interaction with ATRIP",
          "absolute_positon": 501994670,
          "colour": "255,102,0",
          "position": 117209303,
          "chromo": "chr11"
        },
        {
          "amino-acid": "G107-S135",
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          "position": 117222630,
          "chromo": "chr11"
        }
      ]
    }
  },
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        "benign_score": 16,
        "benign_subscore": "Benign",
        "clinical_score": 1.2349999999999999,
        "pathogenic_score": 1,
        "pathogenic_subscore": "Uncertain Significance",
        "total_score": -15,
        "verdict": "Benign"
      },
      "classifications": [
        "BA1",
        "BP6_Very Strong",
        "PVS1_Supporting"
      ]
    },
    "classifications": [
      {
        "name": "BA1",
        "met_criteria": true,
        "user_explain": [
          "GnomAD exomes allele frequency = 0.0639 is greater than 0.05 threshold, good gnomAD exomes coverage = 53.9."
        ]
      },
      {
        "name": "BP6",
        "met_criteria": true,
        "user_explain": [
          "ClinVar classifies this variant as Benign, 2 stars (multiple consistent, reviewed Aug '22, 3 submissions)."
        ],
        "strength": "Very Strong"
      },
      {
        "name": "PVS1",
        "met_criteria": true,
        "user_explain": [
          "Reduced strength as variant has BA1 frequency. null variant (frame-shift) in gene CEP164, predicted to cause NMD. Loss-of-function is a known mechanism of disease (gene has 42 reported pathogenic LOF variants). The exon affects 2 functional domains: UniProt protein CE164_HUMAN region of interest 'Disordered' and UniProt protein CE164_HUMAN region of interest 'Interaction with ATRIP'. The exon contains 4 pathogenic variants. The truncated region contains 40 pathogenic variants."
        ],
        "strength": "Supporting"
      }
    ],
    "gene_id": 4000,
    "sample_findings": {
      "phenotypes": "No matching phenotype found for gene CEP164 which is associated with Ciliopathies, Ciliopathy, Ciliopathy Genes Associated With Cystic Kidney Disease, Genetic Retinal Degeneration Conditions and 7 more, according to CGD, ClinGen Disease Validity, GenCC, Mondo and gene2phenotype.",
      "mode_of_inheritance": "AR, based on gene information from CGD, ClinGen Disease Validity, GenCC, Mondo and gene2phenotype."
    }
  },
  "phylop100way": [
    {
      "version": "13-Apr-2021",
      "conservation_score": [
        "5.763",
        "2.286",
        "0.918",
        "4.849",
        "6.917",
        "3.684",
        "6.943",
        "8.715",
        "1.062",
        "5.822",
        "8.715"
      ]
    }
  ]
}