Available parameters and response documentation is available here

GET /lookup/TP53:R273H?add-AMP-annotation=1
HTTP 200 OK
Allow: GET, HEAD, OPTIONS
Content-Type: application/json ;utf-8
ETag: "344cd110cff2ea349b5a8fe116efe2b12e7118d8"
Vary: Accept

{
  "chromosome": "chr17",
  "alt": "T",
  "ref": "C",
  "pos": 7577120,
  "variant_id": "10190170075771200004",
  "regions": {
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          "GTExJsonData": {
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            "gene_model_positions": {
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              "end": 7580752,
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            },
            "gencode_id": "ENSG00000141510",
            "expressions": {
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              "Small Intestine - Terminal Ileum": 0.863523,
              "Skin - Sun Exposed (Lower leg)": 1.59787,
              "Skin - Not Sun Exposed (Suprapubic)": 1.49155,
              "Prostate": 0.7127350000000001,
              "Pituitary": 0.32462500000000005,
              "Pancreas": 0.443767,
              "Ovary": 1.10353,
              "Nerve - Tibial": 0.848156,
              "Muscle - Skeletal": 0.34056900000000007,
              "Minor Salivary Gland": 0.9606460000000001,
              "Lung": 0.6229350000000001,
              "Liver": 0.296197,
              "Kidney - Medulla": 0.7093740000000001,
              "Kidney - Cortex": 0.394737,
              "Heart - Left Ventricle": 0.26335000000000003,
              "Heart - Atrial Appendage": 0.35228600000000004,
              "Fallopian Tube": 0.907222,
              "Esophagus - Muscularis": 0.536784,
              "Brain - Cortex": 0.21897800000000003,
              "Brain - Cerebellum": 0.08970420000000004,
              "Brain - Cerebellar Hemisphere": 0.07923550000000003,
              "Brain - Caudate (basal ganglia)": 0.252833,
              "Brain - Anterior cingulate cortex (BA24)": 0.18238600000000002,
              "Brain - Amygdala": 0.20558,
              "Bladder": 1.03823,
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              "Artery - Coronary": 0.756963,
              "Artery - Aorta": 0.7235400000000001,
              "Adrenal Gland": 0.6820020000000001,
              "Adipose - Visceral (Omentum)": 0.838552,
              "Adipose - Subcutaneous": 1.00077,
              "Brain - Frontal Cortex (BA9)": 0.14934700000000004,
              "Brain - Hippocampus": 0.15232400000000001,
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              "Brain - Nucleus accumbens (basal ganglia)": 0.18963700000000003,
              "Brain - Putamen (basal ganglia)": 0.20409100000000002,
              "Brain - Spinal cord (cervical c-1)": 0.173358,
              "Brain - Substantia nigra": 0.19410300000000003,
              "Breast - Mammary Tissue": 1.0802,
              "Cells - Cultured fibroblasts": 1.56027,
              "Cells - EBV-transformed lymphocytes": 4.459280000000001,
              "Cervix - Ectocervix": 1.02824,
              "Cervix - Endocervix": 1.08289,
              "Colon - Sigmoid": 0.6092920000000001,
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              "Esophagus - Gastroesophageal Junction": 0.6170760000000001,
              "Esophagus - Mucosa": 1.14474
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            "exon_number": "7",
            "exon_id": "ENSG00000141510.16_7"
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          "position": 7577020,
          "chromo": "chr17"
        }
      ]
    },
    "UNIPROT UniProt Regions": {
      "20-Jun-2022": [
        {
          "amino-acid": "Q100-K370",
          "protein": "P53_HUMAN",
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          "description": "Interaction with HIPK1",
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          "colour": "255,102,0",
          "position": 7572999,
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        },
        {
          "PubMedIds": "25732823",
          "amino-acid": "M1-K320",
          "protein": "P53_HUMAN",
          "type": "region of interest",
          "length": 3027,
          "description": "Interaction with CCAR2",
          "absolute_positon": 1076666330,
          "colour": "255,102,0",
          "position": 7576886,
          "chromo": "chr17"
        },
        {
          "PubMedIds": "17719541",
          "amino-acid": "Q100-P300",
          "protein": "P53_HUMAN",
          "type": "region of interest",
          "length": 2352,
          "description": "Required for interaction with ZNF385A",
          "absolute_positon": 1076666482,
          "colour": "255,102,0",
          "position": 7577038,
          "chromo": "chr17"
        },
        {
          "PubMedIds": "10644996",
          "amino-acid": "T256-E294",
          "protein": "P53_HUMAN",
          "type": "region of interest",
          "length": 460,
          "description": "Interaction with E4F1",
          "absolute_positon": 1076666500,
          "colour": "255,102,0",
          "position": 7577056,
          "chromo": "chr17"
        },
        {
          "amino-acid": "S116-K292",
          "protein": "P53_HUMAN",
          "type": "region of interest",
          "length": 2280,
          "description": "Interaction with AXIN1",
          "absolute_positon": 1076666506,
          "colour": "255,102,0",
          "position": 7577062,
          "chromo": "chr17"
        },
        {
          "PubMedIds": "18996393,16793544,20364130",
          "amino-acid": "T102-K292",
          "protein": "P53_HUMAN",
          "type": "DNA-binding domain",
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          "description": "DNA-binding region_102-292",
          "absolute_positon": 1076666506,
          "colour": "0,153,51",
          "position": 7577062,
          "chromo": "chr17"
        },
        {
          "amino-acid": "R273-R280",
          "protein": "P53_HUMAN",
          "type": "region of interest",
          "length": 24,
          "description": "Interaction with DNA",
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          "colour": "255,102,0",
          "position": 7577098,
          "chromo": "chr17"
        }
      ]
    }
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  "variant_type": "SNV",
  "cytobands": "17p13.1-17p13.1",
  "refseq_transcripts": [
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                ""
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                {
                  "symbols": {
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              ],
              "date_updated": 20220115,
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              ],
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              "accession_id": "SCV002059231"
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            {
              "submitter_date": 20201216,
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                ""
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                {
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              "accession_id": "SCV001478190"
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              "submitter_date": 20170622,
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                ""
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                {
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              "date_updated": 20141019,
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              "accession_id": "SCV000677727"
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            {
              "submitter_date": 20140808,
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                ""
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                {
                  "symbols": {
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              ],
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            {
              "pub_med_references": [
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                8423216
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                "Malkin et al. (1992) identified a germline CGT-to-CAT mutation in exon 8 of the p53 gene that converted arg273 to his (R273H). The proband was a male in whom soft-tissue sarcoma was discovered at the age of 22 years and gastric carcinoma at the age of 30 years (see LFS; 151623).",
                "In 5 of 6 anaplastic carcinomas of the thyroid and in an anaplastic carcinoma thyroid cell line ARO, Fagin et al. (1993) identified the R273H mutation. The presence of p53 mutations almost exclusively in poorly differentiated thyroid tumors and thyroid cancer cell lines suggested that inactivation of p53 may confer these neoplasms with aggressive properties and may further loss of differentiated function.",
                ""
              ],
              "review_date": 19930101,
              "submitter_date": 20130409,
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                {
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              "accession_id": "SCV000033410"
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          ]
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        {
          "variation_id": 12366,
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          "allele_id": 27405,
          "review_description": "Pathogenic",
          "title": "NM_000546.6(TP53):c.818G>A (p.Arg273His) AND not provided",
          "date_created": 20161028,
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            {
              "symbols": {
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                "None Provided"
              ]
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                {
                  "names": [
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                  ]
                }
              ],
              "date_updated": 20220528,
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              "accession_id": "SCV000149647"
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            {
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                ""
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                {
                  "names": [
                    "Not Provided"
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              "date_updated": 20210731,
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            {
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            {
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            {
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        {
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        {
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        {
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        {
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          "title": "NM_000546.6(TP53):c.818G>A (p.Arg273His) AND Glioblastoma",
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          "review_status": "no assertion criteria provided",
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            {
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                "medgen": "C0017636",
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                "mondo": "MONDO:0018177"
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                "Glioblastoma"
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                "Glioblastoma",
                "Giant Cell Glioblastoma (Histologic Variant)",
                "Gliosarcoma (Histologic Variant)"
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            ""
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                ""
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              "accession_id": "SCV000504675"
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        {
          "variation_id": 12366,
          "accession_id": "RCV000435547",
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          "title": "NM_000546.6(TP53):c.818G>A (p.Arg273His) AND Carcinoma of esophagus",
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          "review_status": "no assertion criteria provided",
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            {
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                "Carcinoma of Esophagus"
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            {
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                ""
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              "accession_id": "SCV000504672"
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        {
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          "accession_id": "RCV000434044",
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          "title": "NM_000546.6(TP53):c.818G>A (p.Arg273His) AND Brainstem glioma",
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            {
              "symbols": {
                "medgen": "C0677865",
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                "human_phenotype_ontology": "HP:0010796"
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                "Brainstem Glioma"
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                "Adult Brainstem Glioma"
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            "Likely pathogenic"
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            ""
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              "accession_id": "SCV000504669"
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          "review_status": "no assertion criteria provided",
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            {
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              "pub_med": [
                23562183,
                25311215,
                24627688,
                29355391,
                29398453
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                "Lung Adenocarcinoma",
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              "normalized_cancer": [
                "Lung Adenocarcinoma In Situ"
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                "Lung Cancer"
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              "accession_id": "SCV000504683"
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                "Squamous Cell Lung Carcinoma"
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                "Lung Squamous Cell Carcinoma",
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              "names": [
                "Squamous Cell Lung Carcinoma",
                "Lung Cancer, Squamous Cell, Somatic",
                "Squamous Cell Lung Carcinoma"
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            {
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                "Gastric Adenocarcinoma"
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                "Uterine Carcinosarcoma/Uterine Malignant Mixed Mullerian Tumor"
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              "names": [
                "B-Cell Chronic Lymphocytic Leukemia",
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                "Leukemia, B-Cell, Chronic",
                "B-Cell Chronic Lymphocytic Leukemia"
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          "accession_id": "RCV000429822",
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          "title": "NM_000546.6(TP53):c.818G>A (p.Arg273His) AND Transitional cell carcinoma of the bladder",
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            {
              "symbols": {
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                "mondo": "MONDO:0005611",
                "human_phenotype_ontology": "HP:0006740"
              },
              "normalized_phenotype": [
                "Transitional Cell Carcinoma Of The Bladder"
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          ],
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          "variant_id": 10190170075771200004,
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        {
          "variation_id": 12366,
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          "title": "NM_000546.6(TP53):c.818G>A (p.Arg273His) AND Malignant neoplasm of body of uterus",
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        {
          "variation_id": 12366,
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          "title": "NM_000546.6(TP53):c.818G>A (p.Arg273His) AND Malignant melanoma of skin",
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                "Melanoma, Cutaneous Malignant, Susceptibility to, 1"
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                "Cutaneous Melanoma"
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              "names": [
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                "Melanoma, Cutaneous Malignant, Susceptibility to, 1",
                "Cutaneous Melanoma"
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        {
          "variation_id": 12366,
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          "title": "NM_000546.6(TP53):c.818G>A (p.Arg273His) AND Neoplasm",
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          "review_status": "no assertion criteria provided",
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            {
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                "Neoplasm (disease)"
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                "Neoplasms",
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              "keyword": "neoplasm"
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            "Likely pathogenic"
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                ""
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                {
                  "symbols": {
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              "method": "literature only",
              "clinical_significance": [
                "Likely pathogenic"
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              "review_status": "no assertion criteria provided",
              "accession_id": "SCV000504684"
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        {
          "pub_med_references": [
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            8423216
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          "accession_id": "RCV000013164",
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          "review_description": "Pathogenic",
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            {
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                "human_phenotype_ontology": "HP:0011779"
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                "Thyroid Gland Undifferentiated (Anaplastic) Carcinoma"
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                "Anaplastic Thyroid Cancer"
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              "names": [
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                "Thyroid Gland Undifferentiated (Anaplastic) Carcinoma",
                "Thyroid Gland Undifferentiated (Anaplastic) Carcinoma",
                "Thyroid Carcinoma, Anaplastic, Somatic"
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              "keyword": "Neoplasm"
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          ],
          "title": "NM_000546.6(TP53):c.818G>A (p.Arg273His) AND Thyroid gland undifferentiated (anaplastic) carcinoma",
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            "Malkin et al. (1992) identified a germline CGT-to-CAT mutation in exon 8 of the p53 gene that converted arg273 to his (R273H). The proband was a male in whom soft-tissue sarcoma was discovered at the age of 22 years and gastric carcinoma at the age of 30 years (see LFS; 151623).",
            "In 5 of 6 anaplastic carcinomas of the thyroid and in an anaplastic carcinoma thyroid cell line ARO, Fagin et al. (1993) identified the R273H mutation. The presence of p53 mutations almost exclusively in poorly differentiated thyroid tumors and thyroid cancer cell lines suggested that inactivation of p53 may confer these neoplasms with aggressive properties and may further loss of differentiated function.",
            ""
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                "Malkin et al. (1992) identified a germline CGT-to-CAT mutation in exon 8 of the p53 gene that converted arg273 to his (R273H). The proband was a male in whom soft-tissue sarcoma was discovered at the age of 22 years and gastric carcinoma at the age of 30 years (see LFS; 151623).",
                "In 5 of 6 anaplastic carcinomas of the thyroid and in an anaplastic carcinoma thyroid cell line ARO, Fagin et al. (1993) identified the R273H mutation. The presence of p53 mutations almost exclusively in poorly differentiated thyroid tumors and thyroid cancer cell lines suggested that inactivation of p53 may confer these neoplasms with aggressive properties and may further loss of differentiated function.",
                ""
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                {
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                "Head and Neck Squamous Cell Carcinoma",
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                "Head and Neck Squamous Cell Carcinoma"
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              "keyword": "Hereditary cancer syndrome"
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          "variant_id": 10190170075771200004,
          "date_created": 20170308,
          "title": "NM_000546.6(TP53):c.818G>A (p.Arg273His) AND Squamous cell carcinoma of the head and neck",
          "clinical_significance": [
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            {
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              "disease_mechanism": "loss of function"
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          "title": "NM_000546.6(TP53):c.818G>A (p.Arg273His) AND Malignant tumor of breast",
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      "mutation_id": "MU24637",
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        },
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      "total_samples": 863,
      "oncotree_code": [
        {
          "key": "ADNOS",
          "value": 123
        },
        {
          "key": "SCCNOS",
          "value": 96
        },
        {
          "key": "BREAST",
          "value": 76
        },
        {
          "key": "OVARY",
          "value": 74
        },
        {
          "key": "BOWEL",
          "value": 51
        },
        {
          "key": "GB",
          "value": 32
        },
        {
          "key": "AASTR",
          "value": 16
        },
        {
          "key": "ASTR",
          "value": 13
        },
        {
          "key": "PANCREAS",
          "value": 11
        },
        {
          "key": "OS",
          "value": 10
        },
        {
          "key": "BLADDER",
          "value": 9
        },
        {
          "key": "GINETES",
          "value": 9
        },
        {
          "key": "HCC",
          "value": 5
        },
        {
          "key": "STOMACH",
          "value": 5
        },
        {
          "key": "MCL",
          "value": 5
        },
        {
          "key": "GNOS",
          "value": 5
        },
        {
          "key": "AML",
          "value": 5
        },
        {
          "key": "BRAIN",
          "value": 5
        },
        {
          "key": "PENIS",
          "value": 4
        },
        {
          "key": "LMS",
          "value": 3
        },
        {
          "key": "NHL",
          "value": 3
        },
        {
          "key": "ES",
          "value": 2
        },
        {
          "key": "RCC",
          "value": 2
        },
        {
          "key": "ATLL",
          "value": 2
        },
        {
          "key": "BCC",
          "value": 2
        },
        {
          "key": "ODG",
          "value": 2
        },
        {
          "key": "MFH",
          "value": 2
        },
        {
          "key": "LIPO",
          "value": 2
        },
        {
          "key": "BYST",
          "value": 2
        },
        {
          "key": "CHOL",
          "value": 2
        },
        {
          "key": "CERVIX",
          "value": 1
        },
        {
          "key": "VULVA",
          "value": 1
        },
        {
          "key": "UTERUS",
          "value": 1
        },
        {
          "key": "TLGL",
          "value": 1
        },
        {
          "key": "CHS",
          "value": 1
        },
        {
          "key": "SKIN",
          "value": 1
        },
        {
          "key": "AMML",
          "value": 1
        },
        {
          "key": "RMS",
          "value": 1
        },
        {
          "key": "MEL",
          "value": 1
        },
        {
          "key": "AODG",
          "value": 1
        },
        {
          "key": "GSARC",
          "value": 1
        },
        {
          "key": "BL",
          "value": 1
        },
        {
          "key": "MUCC",
          "value": 1
        },
        {
          "key": "MPNST",
          "value": 1
        }
      ],
      "cancer_name": [
        {
          "key": "Carcinoma, NOS",
          "value": 202
        },
        {
          "key": "Adenocarcinoma, NOS",
          "value": 123
        },
        {
          "key": "Cancer, NOS",
          "value": 106
        },
        {
          "key": "Squamous cell carcinoma, NOS",
          "value": 96
        },
        {
          "key": "Serous cystadenocarcinoma, NOS (C56.9)",
          "value": 42
        },
        {
          "key": "Glioblastoma, NOS (C71._)",
          "value": 32
        },
        {
          "key": "Non-small cell carcinoma (C34._)",
          "value": 22
        },
        {
          "key": "Astrocytoma, anaplastic (C71._)",
          "value": 16
        },
        {
          "key": "Infiltrating duct carcinoma, NOS (C50._)",
          "value": 14
        },
        {
          "key": "Astrocytoma, NOS (C71._)",
          "value": 13
        },
        {
          "key": "Osteosarcoma, NOS (C40._, C41._)",
          "value": 10
        },
        {
          "key": "Tubular adenocarcinoma",
          "value": 9
        },
        {
          "key": "Endometrioid adenocarcinoma, NOS",
          "value": 8
        },
        {
          "key": "B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma",
          "value": 8
        },
        {
          "key": "Carcinoma, anaplastic, NOS",
          "value": 8
        },
        {
          "key": "Transitional cell carcinoma, NOS",
          "value": 7
        },
        {
          "key": "Mucinous adenocarcinoma",
          "value": 7
        },
        {
          "key": "Adenocarcinoma, intestinal type (C16._)",
          "value": 6
        },
        {
          "key": "Malignant lymphoma, large B-cell, diffuse, NOS",
          "value": 6
        },
        {
          "key": "Hepatocellular carcinoma, NOS (C22.0)",
          "value": 5
        },
        {
          "key": "NK/T-cell lymphoma, nasal and nasal-type",
          "value": 5
        },
        {
          "key": "Mantle cell lymphoma",
          "value": 5
        },
        {
          "key": "Glioma, malignant (C71._)",
          "value": 5
        },
        {
          "key": "Papillary serous cystadenocarcinoma (C56.9)",
          "value": 5
        },
        {
          "key": "Acute myeloid leukemia, NOS",
          "value": 5
        },
        {
          "key": "Giant cell glioblastoma (C71._)",
          "value": 4
        },
        {
          "key": "Adenocarcinoma, diffuse type (C16._)",
          "value": 4
        },
        {
          "key": "Leiomyosarcoma, NOS",
          "value": 3
        },
        {
          "key": "Malignant lymphoma, non-Hodgkin, NOS",
          "value": 3
        },
        {
          "key": "Infiltrating ductular carcinoma (C50._)",
          "value": 3
        },
        {
          "key": "Myelodysplastic syndrome, NOS",
          "value": 3
        },
        {
          "key": "Neoplasm, NOS",
          "value": 3
        },
        {
          "key": "Mesodermal mixed tumor",
          "value": 2
        },
        {
          "key": "Mixed glioma (C71._)",
          "value": 2
        },
        {
          "key": "Mullerian mixed tumor (C54._)",
          "value": 2
        },
        {
          "key": "Normal tissue",
          "value": 2
        },
        {
          "key": "Oligodendroglioma, NOS (C71._)",
          "value": 2
        },
        {
          "key": "Malignant fibrous histiocytoma",
          "value": 2
        },
        {
          "key": "Liposarcoma, NOS",
          "value": 2
        },
        {
          "key": "Papillary carcinoma, NOS",
          "value": 2
        },
        {
          "key": "Renal cell carcinoma, NOS (C64.9)",
          "value": 2
        },
        {
          "key": "Signet ring cell carcinoma",
          "value": 2
        },
        {
          "key": "Yolk sac tumor",
          "value": 2
        },
        {
          "key": "Atypical adenoma",
          "value": 2
        },
        {
          "key": "Carcinoma in situ, NOS",
          "value": 2
        },
        {
          "key": "Large cell carcinoma, NOS",
          "value": 2
        },
        {
          "key": "Cholangiocarcinoma (C22.1, C24.0)",
          "value": 2
        },
        {
          "key": "Basal cell carcinoma, NOS (C44._)",
          "value": 2
        },
        {
          "key": "Dysplasia, severe",
          "value": 2
        },
        {
          "key": "Ewing sarcoma",
          "value": 2
        },
        {
          "key": "Follicular adenocarcinoma, NOS (C73.9)",
          "value": 2
        },
        {
          "key": "Adult T-cell leukemia/lymphoma (HTLV-1 positive)",
          "value": 2
        },
        {
          "key": "Adenoma, NOS",
          "value": 2
        },
        {
          "key": "Rhabdomyosarcoma, NOS",
          "value": 1
        },
        {
          "key": "Small cell carcinoma, NOS",
          "value": 1
        },
        {
          "key": "Carcinosarcoma, NOS",
          "value": 1
        },
        {
          "key": "Splenic marginal zone-B-cell lymphoma (C42.2)",
          "value": 1
        },
        {
          "key": "Pseudosarcomatous carcinoma",
          "value": 1
        },
        {
          "key": "Adenofibroma, NOS (C56.9)",
          "value": 1
        },
        {
          "key": "Precursor cell lymphoblastic lymphoma, NOS",
          "value": 1
        },
        {
          "key": "Precursor cell lymphoblastic leukemia, NOS",
          "value": 1
        },
        {
          "key": "Plasma cell leukemia (C42.1)",
          "value": 1
        },
        {
          "key": "T-cell large granular lymphocytic leukemia",
          "value": 1
        },
        {
          "key": "Adenocarcinoma, endocervical type",
          "value": 1
        },
        {
          "key": "Adenocarcinoma with squamous metaplasia",
          "value": 1
        },
        {
          "key": "Burkitt cell leukemia",
          "value": 1
        },
        {
          "key": "Papillary adenocarcinoma, NOS",
          "value": 1
        },
        {
          "key": "Acute myelomonocytic leukemia",
          "value": 1
        },
        {
          "key": "Malignant peripheral nerve sheath tumor",
          "value": 1
        },
        {
          "key": "Hemangiosarcoma",
          "value": 1
        },
        {
          "key": "Goblet cell carcinoid",
          "value": 1
        },
        {
          "key": "Gliosarcoma (C71._)",
          "value": 1
        },
        {
          "key": "Malignant lymphoma, large B-cell, diffuse, immunoblastic, NOS",
          "value": 1
        },
        {
          "key": "Malignant lymphoma, mixed small and large cell, diffuse",
          "value": 1
        },
        {
          "key": "Gastrointestinal stromal sarcoma",
          "value": 1
        },
        {
          "key": "Malignant lymphoma, small B lymphocytic, NOS",
          "value": 1
        },
        {
          "key": "Malignant melanoma, NOS",
          "value": 1
        },
        {
          "key": "Oligodendroglioma, anaplastic (C71._)",
          "value": 1
        },
        {
          "key": "Follicular lymphoma, grade 2",
          "value": 1
        },
        {
          "key": "Fibrillary astrocytoma (C71._)",
          "value": 1
        },
        {
          "key": "Mucoepidermoid carcinoma",
          "value": 1
        },
        {
          "key": "Myelodysplastic syndrome with 5q deletion",
          "value": 1
        },
        {
          "key": "Ductal carcinoma in situ, solid type (C50._)",
          "value": 1
        },
        {
          "key": "Clear cell adenocarcinoma, NOS",
          "value": 1
        },
        {
          "key": "Chondrosarcoma, NOS (C40._, C41._)",
          "value": 1
        },
        {
          "key": "Carcinoma, undifferentiated, NOS",
          "value": 1
        }
      ],
      "cancer_type": [
        {
          "key": "Cancer of Unknown Primary",
          "value": 219
        },
        {
          "key": "Breast Cancer, NOS",
          "value": 76
        },
        {
          "key": "Ovarian/Fallopian Tube Cancer, NOS",
          "value": 74
        },
        {
          "key": "Glioma",
          "value": 70
        },
        {
          "key": "Bowel Cancer, NOS",
          "value": 51
        },
        {
          "key": "Non-small cell carcinoma (C34._)",
          "value": 22
        },
        {
          "key": "Infiltrating duct carcinoma, NOS (C50._)",
          "value": 14
        },
        {
          "key": "Bone Cancer",
          "value": 13
        },
        {
          "key": "Pancreatic Cancer, NOS",
          "value": 11
        },
        {
          "key": "Esophagogastric Cancer",
          "value": 9
        },
        {
          "key": "Bladder/Urinary Tract Cancer, NOS",
          "value": 9
        },
        {
          "key": "Tubular adenocarcinoma",
          "value": 9
        },
        {
          "key": "Soft Tissue Sarcoma",
          "value": 8
        },
        {
          "key": "Endometrioid adenocarcinoma, NOS",
          "value": 8
        },
        {
          "key": "Carcinoma, anaplastic, NOS",
          "value": 8
        },
        {
          "key": "B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma",
          "value": 8
        },
        {
          "key": "Hepatobiliary Cancer",
          "value": 7
        },
        {
          "key": "Transitional cell carcinoma, NOS",
          "value": 7
        },
        {
          "key": "Mucinous adenocarcinoma",
          "value": 7
        },
        {
          "key": "Mature B-Cell Neoplasms",
          "value": 6
        },
        {
          "key": "Malignant lymphoma, large B-cell, diffuse, NOS",
          "value": 6
        },
        {
          "key": "Adenocarcinoma, intestinal type (C16._)",
          "value": 6
        },
        {
          "key": "Leukemia",
          "value": 6
        },
        {
          "key": "NK/T-cell lymphoma, nasal and nasal-type",
          "value": 5
        },
        {
          "key": "Esophageal/Stomach Cancer, NOS",
          "value": 5
        },
        {
          "key": "CNS/Brain Cancer, NOS",
          "value": 5
        },
        {
          "key": "Adenocarcinoma, diffuse type (C16._)",
          "value": 4
        },
        {
          "key": "Penile Cancer, NOS",
          "value": 4
        },
        {
          "key": "Infiltrating ductular carcinoma (C50._)",
          "value": 3
        },
        {
          "key": "Non-Hodgkin Lymphoma",
          "value": 3
        },
        {
          "key": "Mature T and NK Neoplasms",
          "value": 3
        },
        {
          "key": "Neoplasm, NOS",
          "value": 3
        },
        {
          "key": "Mullerian mixed tumor (C54._)",
          "value": 2
        },
        {
          "key": "Papillary carcinoma, NOS",
          "value": 2
        },
        {
          "key": "Renal Cell Carcinoma",
          "value": 2
        },
        {
          "key": "Adenoma, NOS",
          "value": 2
        },
        {
          "key": "Atypical adenoma",
          "value": 2
        },
        {
          "key": "Large cell carcinoma, NOS",
          "value": 2
        },
        {
          "key": "Follicular adenocarcinoma, NOS (C73.9)",
          "value": 2
        },
        {
          "key": "Mixed glioma (C71._)",
          "value": 2
        },
        {
          "key": "Mesodermal mixed tumor",
          "value": 2
        },
        {
          "key": "Signet ring cell carcinoma",
          "value": 2
        },
        {
          "key": "Skin Cancer, Non-Melanoma",
          "value": 2
        },
        {
          "key": "Germ Cell Tumor",
          "value": 2
        },
        {
          "key": "Uterine Cancer, NOS",
          "value": 1
        },
        {
          "key": "Salivary Gland Cancer",
          "value": 1
        },
        {
          "key": "Splenic marginal zone-B-cell lymphoma (C42.2)",
          "value": 1
        },
        {
          "key": "Adenocarcinoma with squamous metaplasia",
          "value": 1
        },
        {
          "key": "Skin Cancer, NOS",
          "value": 1
        },
        {
          "key": "Small cell carcinoma, NOS",
          "value": 1
        },
        {
          "key": "Vulvar/Vaginal Cancer, NOS",
          "value": 1
        },
        {
          "key": "Pseudosarcomatous carcinoma",
          "value": 1
        },
        {
          "key": "Precursor cell lymphoblastic lymphoma, NOS",
          "value": 1
        },
        {
          "key": "Precursor cell lymphoblastic leukemia, NOS",
          "value": 1
        },
        {
          "key": "Plasma cell leukemia (C42.1)",
          "value": 1
        },
        {
          "key": "Papillary adenocarcinoma, NOS",
          "value": 1
        },
        {
          "key": "Nerve Sheath Tumor",
          "value": 1
        },
        {
          "key": "Melanoma",
          "value": 1
        },
        {
          "key": "Malignant lymphoma, small B lymphocytic, NOS",
          "value": 1
        },
        {
          "key": "Malignant lymphoma, mixed small and large cell, diffuse",
          "value": 1
        },
        {
          "key": "Malignant lymphoma, large B-cell, diffuse, immunoblastic, NOS",
          "value": 1
        },
        {
          "key": "Gastrointestinal stromal sarcoma",
          "value": 1
        },
        {
          "key": "Follicular lymphoma, grade 2",
          "value": 1
        },
        {
          "key": "Ductal carcinoma in situ, solid type (C50._)",
          "value": 1
        },
        {
          "key": "Clear cell adenocarcinoma, NOS",
          "value": 1
        },
        {
          "key": "Cervical Cancer, NOS",
          "value": 1
        },
        {
          "key": "Carcinoma, undifferentiated, NOS",
          "value": 1
        }
      ],
      "tissue_type": [
        {
          "key": "Other",
          "value": 219
        },
        {
          "key": "COLORECTUM, NOS",
          "value": 85
        },
        {
          "key": "CNS/Brain",
          "value": 77
        },
        {
          "key": "Breast",
          "value": 76
        },
        {
          "key": "Ovary/Fallopian Tube",
          "value": 74
        },
        {
          "key": "Bowel",
          "value": 51
        },
        {
          "key": "Non-small cell carcinoma (C34._)",
          "value": 22
        },
        {
          "key": "NASOPHARYNX",
          "value": 15
        },
        {
          "key": "Infiltrating duct carcinoma, NOS (C50._)",
          "value": 14
        },
        {
          "key": "Esophagus/Stomach",
          "value": 14
        },
        {
          "key": "Bone",
          "value": 13
        },
        {
          "key": "Lymphoid",
          "value": 12
        },
        {
          "key": "Pancreas",
          "value": 11
        },
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          "key": "Bladder/Urinary Tract",
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                "pub_med_references": [
                  23415222,
                  23525077,
                  23619168,
                  23700467,
                  23852799,
                  23917401,
                  23960188,
                  24140581,
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                "disease_name": [
                  "Li-Fraumeni syndrome"
                ],
                "annotation_id": "VAR_005995"
              }
            ]
          }
        }
      ]
    }
  ],
  "acmg_annotation": {
    "version_name": "11.6.0",
    "gene_symbol": "TP53",
    "transcript": "ENST00000269305.4",
    "transcript_reason": "MANE select",
    "coding_impact": "missense",
    "blosum_score": -1,
    "verdict": {
      "ACMG_rules": {
        "benign_score": 0,
        "benign_subscore": "Uncertain Significance",
        "clinical_score": 5.277,
        "pathogenic_score": 27,
        "pathogenic_subscore": "Pathogenic",
        "total_score": 27,
        "verdict": "Pathogenic"
      },
      "classifications": [
        "PS3_Very Strong",
        "PP5_Very Strong",
        "PM1_Strong",
        "PM5_Strong",
        "PP3_Moderate",
        "PM2_Supporting"
      ]
    },
    "classifications": [
      {
        "name": "PS3",
        "met_criteria": true,
        "user_explain": [
          "Using strength Very Strong in view of the combined evidence from UniProt Variants and the VarSome community.",
          "A VarSome user has classified this variant as Pathogenic, confirmed by a functional study, mentioned in %%PUBMED:24677579%%.",
          "UniProt Variants classifies this variant as Pathogenic, backed by functional studies (requires user validation) mentioned in 29 articles (%%PUBMED:23103869%%, %%PUBMED:22361929%%, %%PUBMED:21559688%%, %%PUBMED:17692090%%, %%PUBMED:17388661%% and 24 more), and also citing 11 articles (%%PUBMED:24942490%%, %%PUBMED:24936796%%, %%PUBMED:24375041%%, %%PUBMED:24140581%%, %%PUBMED:23960188%% and 6 more), associated with Li-Fraumeni syndrome."
        ],
        "strength": "Very Strong"
      },
      {
        "name": "PP5",
        "met_criteria": true,
        "user_explain": [
          "ClinVar classifies this variant as Pathogenic, 3 stars (expert panel, reviewed Oct '22, 53 submissions), citing 11 articles (%%PUBMED:33372952%%, %%PUBMED:30816478%%, %%PUBMED:30224644%%, %%PUBMED:29979965%%, %%PUBMED:29489754%% and 6 more), associated with Adrenal Cortex Carcinoma and Adrenocortical Carcinoma, Hereditary.",
          "The VarSome community has classified this variant as Pathogenic, citing 6 articles (%%PUBMED:33990091%%, %%PUBMED:30723117%%, %%PUBMED:30126368%%, %%PUBMED:29522266%%, %%PUBMED:29026176%% and %%PUBMED:26466571%%)."
        ],
        "strength": "Very Strong"
      },
      {
        "name": "PM1",
        "met_criteria": true,
        "user_explain": [
          "Hot-spot of length 17 amino-acids has 121 missense/in-frame variants (47 pathogenic variants, 74 uncertain variants and no benign), which qualifies as strong pathogenic.",
          "UniProt protein P53_HUMAN region of interest 'Interaction with DNA' has 59 missense/in-frame variants (27 pathogenic variants, 32 uncertain variants and no benign), which qualifies as supporting pathogenic.",
          "UniProt protein P53_HUMAN DNA-binding domain 'DNA-binding region_102-292' has 1 234 missense/in-frame variants (323 pathogenic variants, 908 uncertain variants and 3 benign variants), which qualifies as supporting pathogenic.",
          "UniProt protein P53_HUMAN region of interest 'Interaction with AXIN1' has 1 169 missense/in-frame variants (303 pathogenic variants, 863 uncertain variants and 3 benign variants), which qualifies as supporting pathogenic.",
          "UniProt protein P53_HUMAN region of interest 'Interaction with E4F1' has 261 missense/in-frame variants (74 pathogenic variants, 187 uncertain variants and no benign), which qualifies as supporting pathogenic.",
          "UniProt protein P53_HUMAN region of interest 'Required for interaction with ZNF385A' has 1 285 missense/in-frame variants (325 pathogenic variants, 957 uncertain variants and 3 benign variants), which qualifies as supporting pathogenic.",
          "UniProt protein P53_HUMAN region of interest 'Interaction with CCAR2' has 1 635 missense/in-frame variants (333 pathogenic variants, 1 278 uncertain variants and 24 benign variants), which qualifies as supporting pathogenic.",
          "UniProt protein P53_HUMAN region of interest 'Interaction with HIPK1' has 1 533 missense/in-frame variants (342 pathogenic variants, 1 165 uncertain variants and 26 benign variants), which qualifies as supporting pathogenic."
        ],
        "strength": "Strong"
      },
      {
        "name": "PM5",
        "met_criteria": true,
        "user_explain": [
          "Alternative variant ##chr17:7577121 G⇒T## (Arg273Ser) is classified Pathogenic, 2 stars, by ClinVar (and confirmed using ACMG).",
          "Alternative variant ##chr17:7577121 G⇒C## (Arg273Gly) is classified Pathogenic by UniProt Variants (and confirmed using ACMG).",
          "Alternative variant ##chr17:7577121 G⇒A## (Arg273Cys) is classified Pathogenic by UniProt Variants (and confirmed using ACMG).",
          "Alternative variant ##chr17:7577120 C⇒G## (Arg273Pro) is classified Likely Pathogenic by the VarSome community (and confirmed using ACMG).",
          "Alternative variant ##chr17:7577120 C⇒A## (Arg273Leu) is classified Pathogenic by UniProt Variants (and confirmed using ACMG).",
          "5 pathogenic alternative variants identified."
        ],
        "strength": "Strong"
      },
      {
        "name": "PP3",
        "met_criteria": true,
        "user_explain": [
          "MetaRNN = 0.851 is between 0.841 and 0.939 ⇒ moderate pathogenic."
        ],
        "strength": "Moderate"
      },
      {
        "name": "PM2",
        "met_criteria": true,
        "user_explain": [
          "Variant not found in gnomAD genomes, good gnomAD genomes coverage = 30.7.",
          "GnomAD exomes homozygous allele count = 0 is less than 2 for AD/AR gene TP53, good gnomAD exomes coverage = 71.7."
        ],
        "strength": "Supporting"
      }
    ],
    "gene_id": 33956,
    "sample_findings": {
      "phenotypes": "No matching phenotype found for gene TP53 which is associated with Ependymoma, intracranial, Adrenal Cortex Carcinoma, Adrenal Cortical Carcinoma, 202300, Adrenal, Breast, Brain, And Lung Sarcoma, Gastrointestinal Cancers, Breast Cancer, Osteosarcoma, Soft Tissue Sarcomas, Brain Tumors, Adrenocortical Carcinoma and 46 more, according to CGD, ClinGen Disease Validity, GenCC, Mondo and gene2phenotype.",
      "mode_of_inheritance": "AD/AR, based on gene information from CGD, ClinGen Disease Validity, GenCC, Mondo and gene2phenotype."
    }
  },
  "amp_annotation": {
    "version_name": "11.6.0",
    "verdict": {
      "tier": "Tier II",
      "approx_score": 2.345
    },
    "classifications": [
      {
        "name": "Crtd",
        "tier": "Tier I",
        "user_explain": {
          "Tier I": [
            "ClinVar classifies this variant as Pathogenic, rated 3 stars related to the following 58 cancers: Acute Myeloid Leukemia, Acute granulocytic leukemia, Acute myelogenous leukemia, Acute non-lymphocytic leukemia, Adrenal cortex carcinoma and 53 more, with 30  somatic submissions, citing 42 articles (%%PUBMED:33372952%%, %%PUBMED:30816478%%, %%PUBMED:30224644%%, %%PUBMED:29979965%%, %%PUBMED:29489754%% and 37 more)."
          ],
          "Tier II": [
            "DoCM reports 25 entries classified Tier II citing 7 articles (%%PUBMED:26619011%%, %%PUBMED:25157968%%, %%PUBMED:24641375%%, %%PUBMED:24487413%%, %%PUBMED:24381225%% and 2 more) related to the following 23 cancers: Acute Myeloid Leukemia, Adrenocortical Carcinoma, Bladder/Urinary Tract, Bowel and 18 more.",
            "CIViC reports 5 entries, 3 x 3-star and 2 x 4-star rated , listing 1 drug: \"Doxorubicin, Methotrexate\" related to the following 3 cancers: Breast, Cancer and Osteosarcoma."
          ]
        },
        "approx_score": 3.2
      },
      {
        "name": "Drug",
        "tier": "Tier II",
        "user_explain": {
          "Tier II": [
            "Cisplatin, Etoposide and Mitomycin (curated), reported by CIViC, related to Esophagus/Stomach - but no patient cancer type was provided for matching.",
            "Doxorubicin and Tamoxifen (curated), reported by CIViC, related to Breast - but no patient cancer type was provided for matching.",
            "Docetaxel and Docetaxel, Selumetinib (curated), reported by CIViC, related to Lung - but no patient cancer type was provided for matching.",
            "Capecitabine, Cetuximab, Oxaliplatin (curated), reported by CIViC, related to Bowel - but no patient cancer type was provided for matching.",
            "Carboplatin, Cisplatin (curated), reported by CIViC, related to Ovary/Fallopian Tube - but no patient cancer type was provided for matching."
          ]
        },
        "approx_score": 5.0
      },
      {
        "name": "Germ",
        "tier": "Tier I",
        "user_explain": {
          "Tier I": [
            "This variant is classified Pathogenic, using ACMG rules PS3_Very Strong, PP5_Very Strong, PM1_Strong, PM5_Strong, PP3_Moderate and PM2_Supporting."
          ]
        },
        "approx_score": 3.1
      },
      {
        "name": "Soma",
        "tier": "Tier I",
        "user_explain": {
          "Tier I": [
            "This variant is reported in 2 937 out of the 42 872 somatic samples for gene TP53, which has 5 872 reported somatic variants. Its GnomAD ƒ = 0.0000159. This is statistically rated Tier I."
          ]
        },
        "total_samples": 2937,
        "approx_score": 2.0
      },
      {
        "name": "Pubs",
        "tier": "Tier I",
        "user_explain": {
          "Tier I": [
            "VarSome users have linked 7 articles stating the variant is pathogenic (%%PUBMED:33990091%%, %%PUBMED:30723117%%, %%PUBMED:30126368%%, %%PUBMED:29522266%%, %%PUBMED:29026176%% and 2 more)(2 entries have been automatically lifted over from hg38)."
          ]
        },
        "approx_score": 3.0
      },
      {
        "name": "Path",
        "tier": "Tier I",
        "user_explain": {
          "Tier I": [
            "The Human Protein Atlas classifies TP53 as tumour-suppressing."
          ],
          "Tier II": [
            "BioCarta associates gene TP53 with the following 4 cancers: Breast, RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage, Role of BRCA1,  BRCA2 and ATR in Cancer Susceptibility and Tumor Suppressor Arf Inhibits Ribosomal Biogenesis.",
            "Consensus associates gene TP53 with the following 31 cancers: Adenoid Cystic Carcinoma, Basal Cell Carcinoma, Bladder/Urinary Tract, Breast, CNS/Brain and 26 more.",
            "GHR reports that the TP53 gene provides instructions for making a protein called tumor protein p53 (or p53). Also, associates TP53 with the following 8 cancers: Bladder/Urinary Tract, Breast, Cholangiocarcinoma, Head and Neck Squamous Cell Carcinoma, Lung and 3 more.",
            "KEGG reports that gene TP53 is involved in MAPK signaling pathway, Wnt signaling pathway and p53 signaling pathway. Also, associates TP53 with the following 12 cancers: Basal Cell Carcinoma, Bladder/Urinary Tract, Colorectal cancer, Endometrial cancer, Glioma and 7 more.",
            "Mondo associates gene TP53 with the following 8 cancers: B-Cell Chronic Lymphocytic Leukemia, Bone Osteosarcoma, Choroid Plexus Carcinoma, Choroid Plexus Papilloma, Hepatocellular Carcinoma and 3 more."
          ]
        },
        "approx_score": 4.0
      },
      {
        "name": "Type",
        "tier": "Tier III",
        "user_explain": {
          "Tier III": [
            "ACMG rule PVS1 did not trigger.",
            "ACMG rule PM4 did not trigger.",
            "Variant is not predicted splicing: no prediction from ."
          ]
        },
        "approx_score": 2.0
      },
      {
        "name": "Freq",
        "tier": "Tier II",
        "user_explain": {
          "Tier II": [
            "ACMG rule PM2 was triggered with strength Supporting: Variant not found in gnomAD genomes, good gnomAD genomes coverage = 30.7.\nGnomAD exomes homozygous allele count = 0 is less than 2 for AD/AR gene TP53, good gnomAD exomes coverage = 71.7."
          ]
        },
        "approx_score": 2.0
      },
      {
        "name": "Pred",
        "tier": "Tier III",
        "user_explain": {
          "Tier III": [
            "Uncertain Significance computational verdict based on 1 pathogenic prediction from MetaRNN, conflicting with no benign predictions (and 1 uncertain prediction from DANN)."
          ]
        },
        "approx_score": 1.0
      }
    ]
  },
  "cbio_portal": [
    {
      "version": "21-Jun-2022",
      "total_samples": 1406,
      "sample_id": null,
      "sample_type": [
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          "key": "Primary",
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        },
        {
          "key": "Metastasis",
          "value": 332
        },
        {
          "key": "Recurrence",
          "value": 12
        },
        {
          "key": "Metastatic",
          "value": 6
        },
        {
          "key": "First Recurrence",
          "value": 4
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        {
          "key": "Recurrent",
          "value": 3
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        {
          "key": "Tumor Primary",
          "value": 3
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        {
          "key": "Local Recurrence",
          "value": 2
        }
      ],
      "study_name": null,
      "mutation_status": [
        {
          "key": "Somatic",
          "value": 732
        },
        {
          "key": "Somatic_Vs_Pool",
          "value": 3
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        {
          "key": "Germline",
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        {
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          "value": 1
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      ],
      "validation_status": [
        {
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          "value": 75
        },
        {
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          "key": "Not_Done",
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        {
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        {
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      "center": [
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        {
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      "ensp": "ENSP00000269305",
      "ccds": "CCDS11118.1",
      "cdsposition": "818/1182",
      "cdnaposition": "1008/2579",
      "biotype": "Protein_Coding",
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          "value": 2
        },
        {
          "key": "57",
          "value": 2
        },
        {
          "key": "87",
          "value": 2
        },
        {
          "key": "45",
          "value": 2
        },
        {
          "key": "119",
          "value": 1
        },
        {
          "key": "229",
          "value": 1
        },
        {
          "key": "108",
          "value": 1
        },
        {
          "key": "232",
          "value": 1
        },
        {
          "key": "97",
          "value": 1
        },
        {
          "key": "263",
          "value": 1
        },
        {
          "key": "75",
          "value": 1
        },
        {
          "key": "109",
          "value": 1
        },
        {
          "key": "70",
          "value": 1
        },
        {
          "key": "122",
          "value": 1
        },
        {
          "key": "196",
          "value": 1
        },
        {
          "key": "152",
          "value": 1
        },
        {
          "key": "166",
          "value": 1
        },
        {
          "key": "173",
          "value": 1
        },
        {
          "key": "55",
          "value": 1
        },
        {
          "key": "175",
          "value": 1
        },
        {
          "key": "53",
          "value": 1
        },
        {
          "key": "192",
          "value": 1
        }
      ],
      "os_status": [
        {
          "key": "Deceased",
          "value": 559
        },
        {
          "key": "Living",
          "value": 444
        },
        {
          "key": "Ltf",
          "value": 1
        }
      ],
      "race": [
        {
          "key": "European (non-Finnish)",
          "value": 491
        },
        {
          "key": "African",
          "value": 55
        },
        {
          "key": "Latino",
          "value": 30
        },
        {
          "key": "Other",
          "value": 14
        },
        {
          "key": "East Asian",
          "value": 1
        }
      ],
      "tumor_status": [
        {
          "key": "Disease Free",
          "value": 94
        },
        {
          "key": "Recurred",
          "value": 53
        }
      ],
      "dfs_months": [
        {
          "key": "19",
          "value": 13
        },
        {
          "key": "13",
          "value": 12
        },
        {
          "key": "15",
          "value": 9
        },
        {
          "key": "6",
          "value": 7
        },
        {
          "key": "3",
          "value": 6
        },
        {
          "key": "4",
          "value": 5
        },
        {
          "key": "40",
          "value": 5
        },
        {
          "key": "43",
          "value": 5
        },
        {
          "key": "46",
          "value": 5
        },
        {
          "key": "12",
          "value": 4
        },
        {
          "key": "9",
          "value": 4
        },
        {
          "key": "10",
          "value": 4
        },
        {
          "key": "0",
          "value": 4
        },
        {
          "key": "2",
          "value": 4
        },
        {
          "key": "32",
          "value": 3
        },
        {
          "key": "34",
          "value": 3
        },
        {
          "key": "1",
          "value": 3
        },
        {
          "key": "29",
          "value": 3
        },
        {
          "key": "48",
          "value": 3
        },
        {
          "key": "7",
          "value": 3
        },
        {
          "key": "74",
          "value": 3
        },
        {
          "key": "98",
          "value": 3
        },
        {
          "key": "101",
          "value": 3
        },
        {
          "key": "14",
          "value": 3
        },
        {
          "key": "28",
          "value": 3
        },
        {
          "key": "11",
          "value": 3
        },
        {
          "key": "105",
          "value": 3
        },
        {
          "key": "24",
          "value": 3
        },
        {
          "key": "23",
          "value": 2
        },
        {
          "key": "37",
          "value": 2
        },
        {
          "key": "39",
          "value": 2
        },
        {
          "key": "82",
          "value": 2
        },
        {
          "key": "78",
          "value": 2
        },
        {
          "key": "30",
          "value": 2
        },
        {
          "key": "17",
          "value": 2
        },
        {
          "key": "26",
          "value": 2
        },
        {
          "key": "5",
          "value": 2
        },
        {
          "key": "85",
          "value": 1
        },
        {
          "key": "70",
          "value": 1
        },
        {
          "key": "134",
          "value": 1
        },
        {
          "key": "61",
          "value": 1
        },
        {
          "key": "16",
          "value": 1
        },
        {
          "key": "56",
          "value": 1
        },
        {
          "key": "54",
          "value": 1
        },
        {
          "key": "52",
          "value": 1
        },
        {
          "key": "173",
          "value": 1
        },
        {
          "key": "18",
          "value": 1
        },
        {
          "key": "22",
          "value": 1
        },
        {
          "key": "36",
          "value": 1
        },
        {
          "key": "33",
          "value": 1
        },
        {
          "key": "27",
          "value": 1
        }
      ],
      "path_t_stage": [
        {
          "key": "T3",
          "value": 40
        },
        {
          "key": "T2",
          "value": 24
        },
        {
          "key": "T1",
          "value": 11
        },
        {
          "key": "T4A",
          "value": 5
        },
        {
          "key": "T4",
          "value": 4
        },
        {
          "key": "pT3",
          "value": 2
        },
        {
          "key": "T2A",
          "value": 1
        },
        {
          "key": "T2B",
          "value": 1
        },
        {
          "key": "T2b",
          "value": 1
        },
        {
          "key": "T3/T4",
          "value": 1
        },
        {
          "key": "T4b",
          "value": 1
        },
        {
          "key": "pT4",
          "value": 1
        }
      ],
      "pfs_status": [
        {
          "key": "No",
          "value": 74
        },
        {
          "key": "Yes",
          "value": 65
        }
      ],
      "radiation_therapy": [
        {
          "key": "No",
          "value": 64
        },
        {
          "key": "Yes",
          "value": 33
        }
      ],
      "path_n_stage": [
        {
          "key": "N0",
          "value": 30
        },
        {
          "key": "N1",
          "value": 25
        },
        {
          "key": "N2",
          "value": 6
        },
        {
          "key": "N3",
          "value": 6
        },
        {
          "key": "N1A",
          "value": 4
        },
        {
          "key": "N0 (I-)",
          "value": 3
        },
        {
          "key": "N1B",
          "value": 2
        },
        {
          "key": "N2A",
          "value": 2
        },
        {
          "key": "N2B",
          "value": 2
        },
        {
          "key": "NX",
          "value": 2
        },
        {
          "key": "N2C",
          "value": 1
        },
        {
          "key": "N3A",
          "value": 1
        },
        {
          "key": "N3B",
          "value": 1
        },
        {
          "key": "N3a",
          "value": 1
        },
        {
          "key": "Nx",
          "value": 1
        }
      ],
      "path_m_stage": [
        {
          "key": "M0",
          "value": 67
        },
        {
          "key": "M1",
          "value": 5
        },
        {
          "key": "MX",
          "value": 4
        },
        {
          "key": "CM0 (I+)",
          "value": 2
        }
      ],
      "new_tumor_event_after_initial_treatment": [
        {
          "key": "No",
          "value": 55
        },
        {
          "key": "NO",
          "value": 22
        },
        {
          "key": "Yes",
          "value": 22
        },
        {
          "key": "YES",
          "value": 6
        }
      ],
      "ajcc_pathologic_tumor_stage": [
        {
          "key": "STAGE IIB",
          "value": 12
        },
        {
          "key": "Stage IIA",
          "value": 12
        },
        {
          "key": "Stage IIB",
          "value": 10
        },
        {
          "key": "STAGE II",
          "value": 10
        },
        {
          "key": "STAGE IIA",
          "value": 8
        },
        {
          "key": "Stage I",
          "value": 7
        },
        {
          "key": "STAGE IIIA",
          "value": 6
        },
        {
          "key": "STAGE IIIB",
          "value": 6
        },
        {
          "key": "Stage IIIA",
          "value": 5
        },
        {
          "key": "STAGE I",
          "value": 5
        },
        {
          "key": "STAGE III",
          "value": 5
        },
        {
          "key": "STAGE IIIC",
          "value": 5
        },
        {
          "key": "IIB",
          "value": 4
        },
        {
          "key": "Stage IIIC",
          "value": 3
        },
        {
          "key": "STAGE IV",
          "value": 3
        },
        {
          "key": "Stage III",
          "value": 2
        },
        {
          "key": "Stage IIIB",
          "value": 2
        },
        {
          "key": "STAGE IVA",
          "value": 2
        },
        {
          "key": "STAGE IB",
          "value": 2
        },
        {
          "key": "IV",
          "value": 2
        },
        {
          "key": "IB",
          "value": 1
        },
        {
          "key": "Stage IV",
          "value": 1
        },
        {
          "key": "Stage II",
          "value": 1
        },
        {
          "key": "Stage IB",
          "value": 1
        },
        {
          "key": "STAGE IA",
          "value": 1
        },
        {
          "key": "IIA",
          "value": 1
        }
      ],
      "dss_status": [
        {
          "key": "0:Alive Or Dead Tumor Free",
          "value": 79
        },
        {
          "key": "1:Dead With Tumor",
          "value": 23
        },
        {
          "key": "0.0",
          "value": 1
        }
      ],
      "prior_dx": [
        {
          "key": "No",
          "value": 89
        },
        {
          "key": "Yes",
          "value": 1
        }
      ],
      "somatic_status_freq": [
        {
          "key": "Yes",
          "value": 776
        }
      ],
      "grade": [
        {
          "key": "G3",
          "value": 85
        },
        {
          "key": "G2",
          "value": 44
        },
        {
          "key": "IV",
          "value": 5
        },
        {
          "key": "Grade 3",
          "value": 4
        },
        {
          "key": "II",
          "value": 4
        },
        {
          "key": "G4",
          "value": 3
        },
        {
          "key": "GX",
          "value": 2
        },
        {
          "key": "Well Diff",
          "value": 1
        },
        {
          "key": "3 - Poorly differentiated",
          "value": 1
        },
        {
          "key": "WHO Grade IV",
          "value": 1
        },
        {
          "key": "Poor Diff",
          "value": 1
        },
        {
          "key": "Poor",
          "value": 1
        },
        {
          "key": "PD",
          "value": 1
        },
        {
          "key": "Moderately-Poor",
          "value": 1
        },
        {
          "key": "Mod Diff",
          "value": 1
        },
        {
          "key": "High Grade",
          "value": 1
        },
        {
          "key": "G1",
          "value": 1
        }
      ],
      "pub_med_references": [
        1565144,
        8423216,
        15390294,
        15951970,
        17606709,
        18511570,
        23161690,
        25105660,
        26716509,
        26900293
      ],
      "oncotree_code": [
        {
          "key": "COAD",
          "value": 123
        },
        {
          "key": "IDC",
          "value": 99
        },
        {
          "key": "COADREAD",
          "value": 96
        },
        {
          "key": "PAAD",
          "value": 80
        },
        {
          "key": "LUAD",
          "value": 74
        },
        {
          "key": "READ",
          "value": 70
        },
        {
          "key": "STAD",
          "value": 58
        },
        {
          "key": "ESCA",
          "value": 48
        },
        {
          "key": "BOWEL",
          "value": 47
        },
        {
          "key": "USC",
          "value": 46
        },
        {
          "key": "HGSOC",
          "value": 43
        },
        {
          "key": "PRAD",
          "value": 39
        },
        {
          "key": "SOC",
          "value": 28
        },
        {
          "key": "GBM",
          "value": 24
        },
        {
          "key": "NSCLC",
          "value": 22
        },
        {
          "key": "DIFG",
          "value": 20
        },
        {
          "key": "STOMACH",
          "value": 18
        },
        {
          "key": "HNSC",
          "value": 18
        },
        {
          "key": "GEJ",
          "value": 16
        },
        {
          "key": "BRCA",
          "value": 15
        },
        {
          "key": "ESCC",
          "value": 15
        },
        {
          "key": "UCS",
          "value": 15
        },
        {
          "key": "OVARY",
          "value": 14
        },
        {
          "key": "LUSC",
          "value": 13
        },
        {
          "key": "EHCH",
          "value": 13
        },
        {
          "key": "SOFT_TISSUE",
          "value": 12
        },
        {
          "key": "AASTR",
          "value": 12
        },
        {
          "key": "UEC",
          "value": 11
        },
        {
          "key": "BLCA",
          "value": 11
        },
        {
          "key": "AMLMRC",
          "value": 11
        },
        {
          "key": "DASTR",
          "value": 11
        },
        {
          "key": "CUP",
          "value": 10
        },
        {
          "key": "CHOL",
          "value": 10
        },
        {
          "key": "AML",
          "value": 9
        },
        {
          "key": "MDS",
          "value": 9
        },
        {
          "key": "GBC",
          "value": 9
        },
        {
          "key": "TSTAD",
          "value": 8
        },
        {
          "key": "ILC",
          "value": 7
        },
        {
          "key": "CCRCC",
          "value": 7
        },
        {
          "key": "EGC",
          "value": 7
        },
        {
          "key": "IHCH",
          "value": 7
        },
        {
          "key": "ASTR",
          "value": 7
        },
        {
          "key": "SCLC",
          "value": 7
        },
        {
          "key": "OAST",
          "value": 7
        },
        {
          "key": "LMS",
          "value": 6
        },
        {
          "key": "MACR",
          "value": 6
        },
        {
          "key": "BREAST",
          "value": 6
        },
        {
          "key": "ANGS",
          "value": 5
        },
        {
          "key": "GB",
          "value": 5
        },
        {
          "key": "MFH",
          "value": 5
        },
        {
          "key": "OCSC",
          "value": 5
        },
        {
          "key": "CLLSLL",
          "value": 5
        },
        {
          "key": "TMN",
          "value": 4
        },
        {
          "key": "PANCREAS",
          "value": 4
        },
        {
          "key": "UCCC",
          "value": 4
        },
        {
          "key": "CHRCC",
          "value": 4
        },
        {
          "key": "TLL",
          "value": 4
        },
        {
          "key": "UCEC",
          "value": 4
        },
        {
          "key": "OS",
          "value": 3
        },
        {
          "key": "THPD",
          "value": 3
        },
        {
          "key": "ALUCA",
          "value": 3
        },
        {
          "key": "UMEC",
          "value": 3
        },
        {
          "key": "AMPCA",
          "value": 3
        },
        {
          "key": "BRAIN",
          "value": 3
        },
        {
          "key": "OHNCA",
          "value": 3
        },
        {
          "key": "BLL",
          "value": 2
        },
        {
          "key": "MIXED",
          "value": 2
        },
        {
          "key": "OCS",
          "value": 2
        },
        {
          "key": "MNM",
          "value": 2
        },
        {
          "key": "NHL",
          "value": 2
        },
        {
          "key": "PLBMESO",
          "value": 2
        },
        {
          "key": "PROSTATE",
          "value": 2
        },
        {
          "key": "SBC",
          "value": 2
        },
        {
          "key": "GNOS",
          "value": 2
        },
        {
          "key": "BONE",
          "value": 2
        },
        {
          "key": "BRCNOS",
          "value": 2
        },
        {
          "key": "BL",
          "value": 2
        },
        {
          "key": "CSCC",
          "value": 2
        },
        {
          "key": "EPDCA",
          "value": 2
        },
        {
          "key": "THAP",
          "value": 2
        },
        {
          "key": "HCC",
          "value": 2
        },
        {
          "key": "AOAST",
          "value": 2
        },
        {
          "key": "LIVER",
          "value": 2
        },
        {
          "key": "SWDNET",
          "value": 1
        },
        {
          "key": "SCUP",
          "value": 1
        },
        {
          "key": "TEOS",
          "value": 1
        },
        {
          "key": "ISTAD",
          "value": 1
        },
        {
          "key": "SBWDNET",
          "value": 1
        },
        {
          "key": "THYC",
          "value": 1
        },
        {
          "key": "SPDAC",
          "value": 1
        },
        {
          "key": "SCCNOS",
          "value": 1
        },
        {
          "key": "SKCM",
          "value": 1
        },
        {
          "key": "HGNEC",
          "value": 1
        },
        {
          "key": "ACBC",
          "value": 1
        },
        {
          "key": "ALCL",
          "value": 1
        },
        {
          "key": "ARMM",
          "value": 1
        },
        {
          "key": "BILIARY_TRACT",
          "value": 1
        },
        {
          "key": "BRCANOS",
          "value": 1
        },
        {
          "key": "CCBOV",
          "value": 1
        },
        {
          "key": "CCOV",
          "value": 1
        },
        {
          "key": "CSCLC",
          "value": 1
        },
        {
          "key": "DLBCLNOS",
          "value": 1
        },
        {
          "key": "DSTAD",
          "value": 1
        },
        {
          "key": "ET",
          "value": 1
        },
        {
          "key": "GBAD",
          "value": 1
        },
        {
          "key": "GIST",
          "value": 1
        },
        {
          "key": "HGGNOS",
          "value": 1
        },
        {
          "key": "PCM",
          "value": 1
        },
        {
          "key": "ICPN",
          "value": 1
        },
        {
          "key": "IMMC",
          "value": 1
        },
        {
          "key": "KIDNEY",
          "value": 1
        },
        {
          "key": "LUACC",
          "value": 1
        },
        {
          "key": "MAAP",
          "value": 1
        },
        {
          "key": "MBC",
          "value": 1
        },
        {
          "key": "MDLC",
          "value": 1
        },
        {
          "key": "MPN",
          "value": 1
        },
        {
          "key": "NSCLCPD",
          "value": 1
        },
        {
          "key": "OAT",
          "value": 1
        },
        {
          "key": "ODG",
          "value": 1
        },
        {
          "key": "OPHSC",
          "value": 1
        },
        {
          "key": "PAMPCA",
          "value": 1
        }
      ],
      "cancer_name": [
        {
          "key": "Colorectal Cancer",
          "value": 295
        },
        {
          "key": "Esophagogastric Cancer",
          "value": 157
        },
        {
          "key": "Breast Cancer",
          "value": 119
        },
        {
          "key": "Non-Small Cell Lung Cancer",
          "value": 97
        },
        {
          "key": "Glioma",
          "value": 89
        },
        {
          "key": "Pancreatic Cancer",
          "value": 84
        },
        {
          "key": "Endometrial Cancer",
          "value": 81
        },
        {
          "key": "Ovarian Cancer",
          "value": 66
        },
        {
          "key": "Colorectal Carcinoma",
          "value": 47
        },
        {
          "key": "Prostate Cancer",
          "value": 39
        },
        {
          "key": "Hepatobiliary Cancer",
          "value": 31
        },
        {
          "key": "Soft Tissue Sarcoma",
          "value": 27
        },
        {
          "key": "Head and Neck Cancer",
          "value": 25
        },
        {
          "key": "Leukemia",
          "value": 24
        },
        {
          "key": "Non Small Cell Lung Cancer",
          "value": 17
        },
        {
          "key": "Ovarian Carcinoma",
          "value": 14
        },
        {
          "key": "Cancer of Unknown Primary",
          "value": 12
        },
        {
          "key": "Esophageal Carcinoma",
          "value": 11
        },
        {
          "key": "Bladder Cancer",
          "value": 11
        },
        {
          "key": "Renal Cell Carcinoma",
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}